Syntic Life

Publications & references.

Selected literature relevant to epigenetic restoration and the biology of aging.

Curated reading list

Key papers on partial reprogramming and cellular rejuvenation.

  1. Ocampo A, et al. In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming. · Cell · 2016

    View article

  2. Doeser MC, et al. Reduction of Fibrosis and Scar Formation by Partial Reprogramming In Vivo. · Stem Cells · 2018

    View article

  3. Olova N, et al. Partial reprogramming induces a steady decline in epigenetic age before loss of somatic identity. · Aging Cell · 2018

    View article

  4. Lu Y, et al. Reprogramming to recover youthful epigenetic information and restore vision. · Nature · 2020

    View article

  5. Sarkar TJ, et al. Transient non-integrative expression of nuclear reprogramming factors promotes multifaceted amelioration of aging in human cells. · Nature Communications · 2020

    View article

  6. Chen Y, et al. Reversible reprogramming of cardiomyocytes to a fetal state drives heart regeneration in mice. · Science · 2021

    View article

  7. Wang C, et al. In vivo partial reprogramming of myofibers promotes muscle regeneration by remodeling the stem cell niche. · Nature Communications · 2021

    View article

  8. Browder KC, et al. In vivo partial reprogramming alters age-associated molecular changes during physiological aging in mice. · Nature Aging · 2022

    View article

  9. Roux AE, et al. Diverse partial reprogramming strategies restore youthful gene expression and transiently suppress cell identity. · Cell Systems · 2022

    View article

  10. Gill D, et al. Multi-omic rejuvenation of human cells by maturation phase transient reprogramming. · eLife · 2022

    View article

  11. Yang J-H, et al. Loss of Epigenetic Information as a Cause of Mammalian Aging. · Cell · 2023

    View article

  12. Paine P, et al. Partial cellular reprogramming: A deep dive into an emerging rejuvenation technology. · Aging Cell · 2024

    View article

Epigenetics across age-related disease

Representative literature linking epigenetic change to disease across many tissues.

  • Basavarajappa BS, Subbanna S. Histone methylation regulation in neurodegenerative disorders. · Int J Mol Sci · 2021

    View article

  • Berson A, et al. Epigenetic regulation in neurodegenerative diseases. · Trends Neurosci · 2018

    View article

  • Cencioni C, et al. Gastrointestinal cancer patient nutritional management: from specific needs to novel epigenetic dietary approaches. · Nutrients · 2022

    View article

  • Chambers, et al. Widespread rewiring of the DNA methylome and transcriptome with decelerated methylation age after regeneration in aged skeletal muscle. · ARDD poster · 2025

    conference poster — no DOI assigned

  • Chandra A, Rajawat J. Skeletal aging and osteoporosis: mechanisms and therapeutics. · Int J Mol Sci · 2021

    View article

  • Chen L, et al. The effects of epigenetic modification on the occurrence and progression of liver diseases and the involved mechanism. · Expert Rev Gastroenterol Hepatol · 2020

    View article

  • Chen Y, et al. Reversible reprogramming of cardiomyocytes to a fetal state drives heart regeneration in mice. · Science · 2021

    View article

  • Doeser MC, et al. Reduction of fibrosis and scar formation by partial reprogramming in vivo. · Stem Cells · 2018

    View article

  • Egervari G, et al. Molecular windows into the human brain for psychiatric disorders. · Mol Psychiatry · 2019

    View article

  • El Hajj N, et al. Epigenetics and life-long consequences of an adverse nutritional and diabetic intrauterine environment. · Reproduction · 2014

    View article

  • Forsberg SL, et al. Epigenetics and cerebral organoids: promising directions in autism spectrum disorders. · Transl Psychiatry · 2018

    View article

  • Gemenetzi M, Lotery AJ. Epigenetics in age-related macular degeneration: new discoveries and future perspectives. · Cell Mol Life Sci · 2020

    View article

  • Gomez RS, et al. Epigenetics and periodontal disease: future perspectives. · Inflamm Res · 2009

    View article

  • Ibáñez-Cabellos JS, et al. Epigenetic regulation in the pathogenesis of Sjögren syndrome and rheumatoid arthritis. · Front Genet · 2019

    View article

  • Kingma JG, et al. The physiopathology of cardiorenal syndrome: a review of the potential contributions of inflammation. · J Cardiovasc Dev Dis · 2017

    View article

  • Kubota T, et al. Epigenetic understanding of gene-environment interactions in psychiatric disorders: a new concept of clinical genetics. · Clin Epigenetics · 2012

    View article

  • Kuo P-L, et al. Epigenetic age acceleration and hearing: observations from the Baltimore Longitudinal Study of Aging. · Front Aging Neurosci · 2021

    View article

  • Mallik S, et al. Novel epigenetic clock biomarkers of age-related macular degeneration. · Front Med · 2022

    View article

  • Meda F, et al. The epigenetics of autoimmunity. · Cell Mol Immunol · 2011

    View article

  • Minocherhomji S, et al. Epigenetic regulatory mechanisms associated with infertility. · Obstet Gynecol Int · 2010

    View article

  • Muto Y, et al. Epigenetic reprogramming driving successful and failed repair in acute kidney injury. · Sci Adv · 2024

    View article

  • Pardo A, Selman M. The interplay of the genetic architecture, aging, and environmental factors in the pathogenesis of idiopathic pulmonary fibrosis. · Am J Respir Cell Mol Biol · 2021

    View article

  • Picascia A, et al. Epigenetic control of autoimmune diseases: from bench to bedside. · Clin Immunol · 2015

    View article

  • Rui L, Lin JD. Reprogramming of hepatic metabolism and microenvironment in nonalcoholic steatohepatitis. · Annu Rev Nutr · 2022

    View article

  • Schiano C, et al. Epigenetic-related therapeutic challenges in cardiovascular disease. · Trends Pharmacol Sci · 2015

    View article

  • Sheikhpour M, et al. A review of epigenetic changes in asthma: methylation and acetylation. · Clin Epigenetics · 2021

    View article

  • Shi Y, et al. Epigenetic regulation in cardiovascular disease: mechanisms and advances in clinical trials. · Signal Transduct Target Ther · 2022

    View article

  • Talikka M, et al. Genomic impact of cigarette smoke, with application to three smoking-related diseases. · Crit Rev Toxicol · 2012

    View article

  • van Dijk SJ, et al. Epigenetics and human obesity. · Int J Obes · 2015

    View article

  • Visconti VV, et al. DNA methylation signatures of bone metabolism in osteoporosis and osteoarthritis aging-related diseases: an updated review. · Int J Mol Sci · 2021

    View article

  • Wang C, et al. In vivo partial reprogramming of myofibers promotes muscle regeneration by remodeling the stem cell niche. · Nat Commun · 2021

    View article

  • Zhang L, et al. Targeting epigenetics as a promising therapeutic strategy for treatment of neurodegenerative diseases. · Biochem Pharmacol · 2022

    View article

  • Zhao H, et al. Epigenetic therapy targeting bone marrow mesenchymal stem cells for age-related bone diseases. · Stem Cell Res Ther · 2022

    View article

Every DOI link was verified against the publisher record and resolves through doi.org so it stays live even if a journal moves a page. These are third-party publications listed for reference; they are not the work of Syntic Life.

Syntic Life's technologies are in preclinical development and are not approved for human use. Results described were obtained in laboratory and animal models and do not predict outcomes in humans. All research is conducted in compliance with applicable institutional, ethical, and regulatory standards. Statements regarding our research, pipeline, and vision are forward-looking and reflect current scientific hypotheses, not clinical outcomes or regulatory approvals.